Journal article
Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
M Askmyr, KE White, T Jovic, HA King, JM Quach, AC Maluenda, EK Baker, MF Smeets, CR Walkley, LE Purton
Scientific Reports | Published : 2015
DOI: 10.1038/srep15529
Open access
Abstract
The gp130 receptor and its binding partners play a central role in cytokine signalling. Ciliary neurotrophic factor (CNTF) is one of the cytokines that signals through the gp130 receptor complex. CNTF has previously been shown to be a negative regulator of trabecular bone remodelling and important for motor neuron development. Since haematopoietic cell maintenance and differentiation is dependent on the bone marrow (BM) microenvironment, where cells of the osteoblastic lineage are important regulators, we hypothesised that CNTF may also have important roles in regulating haematopoiesis. Analysis of haematopoietic parameters in male and female Cntf/mice at 12 and 24 weeks of age revealed alte..
View full abstractGrants
Funding Acknowledgements
The authors would like to thank SVH BioResources Centre for care of experimental animals. This work was supported in part by grants from the National Health and Medical Research Council of Australia (NHMRC; to L.E.P.); NHMRC Career Development Award (L.E.P.); NHMRC Senior Research Fellowship (L.E.P.); Post-doctoral Fellowship from the Swedish Research Council (M.A.); and in part by the Victorian State Government Operational Infrastructure Support Program (to St. Vincent's Institute). Generous support from the Ian Potter Foundation assisted with the purchase of the mu CT and irradiator used in these studies.