Journal article

Chondroitinase improves midbrain pathway reconstruction by transplanted dopamine progenitors in Parkinsonian mice

Jessica A Kauhausen, Lachlan H Thompson, Clare L Parish

Molecular and Cellular Neuroscience | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015

Abstract

Within the adult central nervous system the lack of guidance cues together with the presence of inhibitory molecules produces an environment that is restrictive to axonal growth following injury. Consequently, while clinical trials in Parkinson's disease (PD) patients have demonstrated the capacity of fetal-derived dopamine neurons to survive, integrate and alleviate symptoms, the non-permissive host environment has contributed to the incomplete re-innervation of the target tissue by ectopic grafts, and even more noticeable, the poor reconstruction of the midbrain dopamine pathways following homotopic midbrain grafting. One such inhibitory molecule is the chondroitin sulfate proteoglycan (CS..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC), Australia (grant #APP1022637). JAK is the recipient of a Strategic Australian Postgraduate Award (STRAPA). LHT was supported by NHMRC Career Development Award. CLP was supported by a Senior Medical Research Fellowship provided by the Viertel Charitable Foundation, Australia. The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant. We thank Ms. Mong Tien for her technical assistance.