Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease
Ting-Yi Wang, Kiara F Bruggeman, Jessica A Kauhausen, Alexandra L Rodriguez, David R Nisbet, Clare L Parish
Biomaterials | ELSEVIER SCI LTD | Published : 2016
With the brain's limited capacity for repair there is a need for new and innovative therapies to promote regeneration. Stem/progenitor cell transplantation has received increasing attention, and whilst clinical trials demonstrating functional integration exist, inherent variability between patients has hindered development of this therapy. Variable outcomes have largely been attributed to poor survival and insufficient reinnervation of target tissues due in part to the suboptimal host environment. Here we examined whether improving the physical properties of the host milieu, by way of bioengineered scaffolds, may enhance engraftment. We developed a composite scaffold, incorporating electrosp..View full abstract
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Awarded by Australian Research Council
This research was supported by funding from the Australian Research Council (DP130103131). The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant. K.F.B was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postgraduate Scholarship Doctoral (PGS D) award; DRN was supported by a NHMRC Career Development Fellowship; CLP was supported by a Senior Medical Research Fellowship provided by the Viertel Charitable Foundation, Australia. Access to the facilities of the Centre for Advanced Microscopy with funding through the Australian Microscopy and Microanalysis Research Facility is gratefully acknowledged. We wish to thank Dr Thomas Gengenbach and the CSIRO for conducting the XPS analysis.