Journal article

Multifrequency Oscillatory Ventilation in the Premature Lung Effects on Gas Exchange, Mechanics, and Ventilation Distribution

David W Kaczka, Jacob Herrmann, C Elroy Zonneveld, David G Tingay, Anna Lavizzari, Peter B Noble, J Jane Pillow

Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

BACKGROUND: Despite the theoretical benefits of high-frequency oscillatory ventilation (HFOV) in preterm infants, systematic reviews of randomized clinical trials do not confirm improved outcomes. The authors hypothesized that oscillating a premature lung with multiple frequencies simultaneously would improve gas exchange compared with traditional single-frequency oscillatory ventilation (SFOV). The goal of this study was to develop a novel method for HFOV, termed "multifrequency oscillatory ventilation" (MFOV), which relies on a broadband flow waveform more suitable for the heterogeneous mechanics of the immature lung. METHODS: Thirteen intubated preterm lambs were randomly assigned to eith..

View full abstract

Grants

Awarded by National Institutes of Health (Bethesda, Maryland)


Awarded by National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia)


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

Support was received from the National Institutes of Health (Bethesda, Maryland; grant no. UM1 HL108724 to Dr. Kaczka and Mr. Herrmann); the National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia; grant no. APP1010575), Women and Infants Research Foundation (Subiaco, Western Australia, Australia), and the Metropolitan Health Research Infrastructure Fund (Perth, Western Australia, Australia) (to Dr. Pillow); National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia; fellowship APP1045824 to Dr. Noble); National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia; fellowship GRP 491286 to Dr. Tingay); and Victorian Government Operational Infrastructure Support Program (Melbourne, Victoria, Australia; to Drs. Tingay and Lavizzari and Mr. Zonneveld).