Journal article
Multifrequency oscillatory ventilation in the premature lung: Effects on gas exchange, mechanics, and ventilation distribution
DW Kaczka, J Herrmann, CE Zonneveld, DG Tingay, A Lavizzari, PB Noble, JJ Pillow
Anesthesiology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
Abstract
Background: Despite the theoretical benefits of high-frequency oscillatory ventilation (HFOV) in preterm infants, systematic reviews of randomized clinical trials do not confirm improved outcomes. The authors hypothesized that oscillating a premature lung with multiple frequencies simultaneously would improve gas exchange compared with traditional single-frequency oscillatory ventilation (SFOV). The goal of this study was to develop a novel method for HFOV, termed "multifrequency oscillatory ventilation" (MFOV), which relies on a broadband flow waveform more suitable for the heterogeneous mechanics of the immature lung. Methods: Thirteen intubated preterm lambs were randomly assigned to eith..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
Support was received from the National Institutes of Health (Bethesda, Maryland; grant no. UM1 HL108724 to Dr. Kaczka and Mr. Herrmann); the National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia; grant no. APP1010575), Women and Infants Research Foundation (Subiaco, Western Australia, Australia), and the Metropolitan Health Research Infrastructure Fund (Perth, Western Australia, Australia) (to Dr. Pillow); National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia; fellowship APP1045824 to Dr. Noble); National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia; fellowship GRP 491286 to Dr. Tingay); and Victorian Government Operational Infrastructure Support Program (Melbourne, Victoria, Australia; to Drs. Tingay and Lavizzari and Mr. Zonneveld).