Journal article
Nitrous oxide and serious long-term morbidity and mortality in the evaluation of nitrous oxide in the gas mixture for anaesthesia (ENIGMA)-II trial
K Leslie, PS Myles, J Kasza, A Forbes, PJ Peyton, MTV Chan, MJ Paech, DI Sessler, WS Beattie, PJ Devereaux, S Wallace
Anesthesiology | Published : 2015
Abstract
Background: The Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial randomly assigned 7,112 noncardiac surgery patients at risk of perioperative cardiovascular events to 70% N2O or 70% N2 groups. The aim of this follow-up study was to determine the effect of nitrous oxide on a composite primary outcome of death and major cardiovascular events at 1 yr after surgery. Methods: One-year follow-up was conducted via a medical record review and telephone interview. Disability was defined as a Katz index of independence in activities of daily living score less than 8. Adjusted odds ratios and hazard ratios were calculated as appropriate for primary and secondary outcomes..
View full abstractGrants
Awarded by Australian and New Zealand College of Anaesthetists Project Grants (Melbourne, Victoria, Australia)
Awarded by National Health and Medical Research Council (Canberra, Australian Capital Territory, Australia)
Awarded by Research Grant Council General Research Fund grant (Hong Kong, Special Administrative Area, People's Repubic of China)
Awarded by Health and Research Grant Council Medical Research Fund grant (Hong Kong, Special Administrative Area, People's Republic of China)
Funding Acknowledgements
This study was supported by Australian and New Zealand College of Anaesthetists Project Grants 10/014 and 12/008 (Melbourne, Victoria, Australia). The Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial was supported by a National Health and Medical Research Council Project Grant (435015) (Canberra, Australian Capital Territory, Australia); a Research Grant Council General Research Fund grant (461409) (Hong Kong, Special Administrative Area, People's Repubic of China); and a Health and Research Grant Council Medical Research Fund grant (11121051) (Hong Kong, Special Administrative Area, People's Republic of China).