The effect of triiodothyronine on the association of the rat apolipoprotein A-I, C-III and A-IV genes with the nuclear matrix

Abstract

The association of apolipoprotein genes with the nuclear matrix of rat liver has been studied. The proportion of the apolipoprotein (apo) A-I, A-IV, C-III and E genes and the albumin gene associated with the matrix in normal rat liver was approximately 11%. In hypothyroid rats, the association of the apo A-I and apo A-IV genes with the matrix was reduced to 1.3% and 2.1% respectively, while in hyperthyroid rats, the association increased to 59% and 39% respectively. In contrast, the association of the apo C-III gene, which is located between the A-I and A-IV genes on chromosome 11, was not significantly affected by thyroid status. The association of the apo E and albumin genes with the matri..