Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina
Andrew C Kotze, Barney M Hines, Neil H Bagnall, Clare A Anstead, Praveer Gupta, Robert C Reid, Angela P Ruffell, David P Fairlie
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | ELSEVIER SCI LTD | Published : 2015
The Australian sheep blowfly, Lucilia cuprina, is an ecto-parasite that causes significant economic losses in the sheep industry. Emerging resistance to insecticides used to protect sheep from this parasite is driving the search for new drugs that act via different mechanisms. Inhibitors of histone deacetylases (HDACs), enzymes essential for regulating eukaryotic gene transcription, are prospective new insecticides based on their capacity to kill human parasites. The blowfly genome was found here to contain five HDAC genes corresponding to human HDACs 1, 3, 4, 6 and 11. The catalytic domains of blowfly HDACs 1 and 3 have high sequence identity with corresponding human and other Dipteran inse..View full abstract
Awarded by Australian Wool Innovation Limited
Awarded by National Health and Medical Research Council
Funding for this work was provided by Australian Wool Innovation Limited (ON-00110), and by the L.W. Bett Bequest. DF acknowledges the National Health and Medical Research Council for a Senior Principal Research Fellowship (1027369) and grants (1093378, 1074016) for developing antiparasitic HDAC inhibitors. CA holds a NSERC Postdoctoral Fellowship. The authors have no conflicts of interest concerning the work reported in this paper.