Journal article
How Well Do Standard Stroke Outcome Measures Reflect Quality of Life? A Retrospective Analysis of Clinical Trial Data
Myzoon Ali, Rachael Fulton, Terry Quinn, Marian Brady
STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013
Abstract
BACKGROUND AND PURPOSE: Quality of life (QoL) is important to stroke survivors yet is often recorded as a secondary measure in acute stroke randomized controlled trials. We examined whether commonly used stroke outcome measures captured aspects of QoL. METHODS: We examined primary outcomes by National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI) and modified Rankin Scale (mRS), and QoL by Stroke Impact Scale (SIS) and European Quality of Life Scale (EQ-5D) from the Virtual International Stroke Trials Archive (VISTA). Using Spearman correlations and logistic regression, we described the relationships between QoL mRS, NIHSS, and BI at 3 months, stratified by respondent (patien..
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Awarded by MRC
Funding Acknowledgements
Drs Ali and Brady and the Nursing, Midwifery and Allied Health Professions Research Unit are funded by the Chief Scientist Office (CSO), Scottish Government's Health Directorate, Scotland. This work was funded as part of a CSO Postdoctoral Fellowship Award. The views expressed here are those of the authors and not necessarily those of the CSO. VISTA is a not-for-profit collaboration of researchers from academia and commercial organizations. The VISTA Steering Committee members have each contributed to the organization of contributing trials, and where these have involved industry support, they have acknowledged that within the original publications.