Journal article
Geography, structure, and evolution of diffusion and perfusion lesions in diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE)
JM Olivot, M Mlynash, VN Thijs, A Purushotham, S Kemp, MG Lansberg, L Wechsler, GE Gold, R Bammer, MP Marks, GW Albers
Stroke | Published : 2009
Abstract
Background and Purpose-: The classical representation of acute ischemic lesions on MRI is a central diffusion-weighted imaging (DWI) lesion embedded in a perfusion-weighted imaging (PWI) lesion. We investigated spatial relationships between final infarcts and early DWI/PWI lesions before and after intravenous thrombolysis in the Diffusion and perfusion imaging Evaluation For Understanding Stroke Evolution (DEFUSE) study. Methods-: Baseline and follow-up DWI and PWI lesions and 30-day fluid-attenuated inversion recovery scans of 32 patients were coregistered. Lesion geography was defined by the proportion of the DWI lesion superimposed by a Tmax (time when the residue function reaches its max..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
The funding for this study was provided by National Institutes of Health (NIH) grants RO1 NS39325, Principal Investigator, Gregory W. Albers; K24 NS044848, Principal Investigator, Gregory W. Albers; and K23 NS051372, Principal Investigator Maarten G. Lansberg. tPA was supplied at no charge by Genentech (US and Canada sites) and Boehringer Ingelheim (Belgium site). Genentech, Boehringer Ingelheim, and the NIH did not play a role in the design and the conduct of the study; collection, management, analysis, and interpretation of the data; or preparation or approval of the manuscript.