Journal article
Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified rankin Scale
MG Lansberg, M Schrooten, E Bluhmki, VN Thijs, JL Saver
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009
Abstract
BACKGROUND AND PURPOSE-: To make informed treatment decisions, patients and physicians need to be aware of the benefits and risks of a proposed treatment. The number needed to treat (NNT) for benefit and harm are intuitive and statistically valid measures to describe a treatment effect. The aim of this study is to calculate treatment time-specific NNT estimates based on shifts over the entire spectrum of clinically relevant functional outcomes. METHODS-: The pooled data set of the first 6 major randomized acute stroke trials of intravenous tissue plasminogen activator was used for this study. The data were stratified by 90-minute treatment time windows. NNT for benefit and NNT for harm estim..
View full abstractGrants
Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
Funding for this study was provided by National Institutes of Health grant K23 NS051372, Principal Investigator, Maarten G. Lansberg, and the "Fonds voor Wetenschappelijk Onderzoek Vlaanderen" and by the Flemish institute of Biotechnology, Principal Investigator, Vincent N. Thijs.