Journal article

Relation Between Migraine and Size of Echocardiographic Intrapulmonary Right-to-Left Shunt

Marco WF van Gent, Johannes J Mager, Repke J Snijder, Cornelis JJ Westermann, Herbert WM Plokker, Wouter J Schonewille, Vincent Thijs, Martijn C Post

The American Journal of Cardiology | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | Published : 2011


An increased prevalence of intrapulmonary right-to-left shunt (RLS) has been shown in patients with migraine. The aim of this study was to determine whether the size of intrapulmonary RLS was associated with migraine with aura (MA+) and migraine without aura (MA-) in subjects screened for hereditary hemorrhagic telangiectasia. A total of 462 consecutive subjects were screened for hereditary hemorrhagic telangiectasia and underwent transthoracic contrast echocardiography. A pulmonary shunt was established when contrast appeared in the left atrium after 4 cardiac cycles. Shunt size was assessed semiquantitatively as small (100 microbubbles). A headache questionnaire was completed by 420 subjec..

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