Journal article

Association of Vascular Risk Factors With Cervical Artery Dissection and Ischemic Stroke in Young Adults

Stephanie Debette, Tiina Metso, Alessandro Pezzini, Sherine Abboud, Antti Metso, Didier Leys, Anna Bersano, Fabien Louillet, Valeria Caso, Chantal Lamy, Elisabeth Medeiros, Yves Samson, Caspar Grond-Ginsbach, Stefan T Engelter, Vincent Thijs, Simone Beretta, Yannick Bejot, Maria Sessa, Maria Lorenza Muiesan, Philippe Amouyel Show all

Circulation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011

Abstract

BACKGROUND: Little is known about the risk factors for cervical artery dissection (CEAD), a major cause of ischemic stroke (IS) in young adults. Hypertension, diabetes mellitus, smoking, hypercholesterolemia, and obesity are important risk factors for IS. However, their specific role in CEAD is poorly investigated. Our aim was to compare the prevalence of vascular risk factors in CEAD patients versus referents and patients who suffered an IS of a cause other than CEAD (non-CEAD IS) in the multicenter Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) study. METHODS AND RESULTS: The study sample comprised 690 CEAD patients (mean age, 44.2 ± 9.9 years; 43.9% women), 556 patients ..

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Funding Acknowledgements

The CADISP study has received funding from the Contrat de Projet Etat-Region 2007, Centre National de Genotypage, Emil Aaltonen Foundation, Paavo Ilmari Ahvenainen Foundation, Helsinki University Central Hospital Research Fund, Academy of Finland, Helsinki University Medical Foundation, Paivikki and Sakari Sohlberg Foundation, Aarne Koskelo Foundation, Maire Taponen Foundation, Aarne and Aili Turunen Foundation, Lilly Foundation, Alfred Kordelin Foundation, Finnish Medical Foundation, Projet Hospitalier de Recherche Clinique Regional 2004, Fondation de France, Genopole de Lille, Adrinord, EA2691, Institut Pasteur de Lille, Inserm U744, Basel Stroke Funds, Kathe-Zingg-Schwichtenberg-Fonds of the Swiss Academy of Medical Sciences, and Swiss Heart Foundation. The Vobarno Study is supported in part by grants from the European Community Network of Excellence (InGenious HyperCare, 2006 to 2010); Italian University and Research Ministry, Regione Lombardia, and Fondazione della Comunita Bresciana Onlus. The MONA-LISA Study was made possible by an unrestricted grant from Pfizer and by a grant from the ANR (ANR-05-PNRA-018). Dr Thijs is supported by FWO Flanders.Dr Metso received research grants from the Helsinki Central Hospital Research Fund, Finnish Medical Foundation, University of Helsinki, Aarne and Aili Turunen Foundation, Emil Aaltonen Foundation, Paaro Illmari Aimenainen Foundation, Paivikki and Sakari Sohlberg Foundation, Aarne Koskelo Foundation, Maire Taponen Foundation, Lilly Foundation, and Alfred Kordelin Foundation. Dr Metso also received research grants from the Finnish Medical Foundation and Alfred Kordelin Foundation. Dr Caso received payment for speakers' bureau appointments from Boehringer Ingelheim-Sanofi. Dr Engelter received a research grant from the Swiss Academy of Medical Sciences and Swiss Heart Foundation.