Journal article
Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke
R Lemmens, S Abboud, W Robberecht, L Vanhees, M Pandolfo, V Thijs, A Goris
European Journal of Human Genetics | Published : 2009
DOI: 10.1038/ejhg.2009.42
Abstract
Recently, genome-wide analyses revealed that variants on chromosome 9p21 are associated with myocardial infarction. We investigated whether this association was also present in a Belgian population of coronary artery disease (CAD) patients. As CAD and ischemic cerebrovascular disease (CVD) are thought to share some pathogenic pathways, we further examined the association of 9p21 with this disease. SNP rs10757278 on chromosome 9 was genotyped in 926 patients with CAD from the CAREGENE study, in 648 patients with CVD from the Leuven Stroke Genetics Study (LSGS) and the Belgian Stroke Study (BSS) and in 828 unrelated controls. A systematic review and meta-analysis were carried out in both vascu..
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Funding Acknowledgements
The BSS was supported by the Erasme Funds. AG is a Postdoctoral Fellow of the Research Fund Flanders (FWO-Vlaanderen). Vincent This is supported by FWO Research Foundation Flanders. WR is supported through the E von Behring Chair for Neuromuscular and Neurodegenerative Disorders, and by the Interuniversity Attraction Poles (IUAP) program P6/43 of the Belgian Federal Science Policy Office.