Journal article
Relationships Between Cerebral Perfusion and Reversibility of Acute Diffusion Lesions in DEFUSE: Insights from RADAR
JM Olivot, M Mlynash, VN Thijs, A Purushotham, S Kemp, MG Lansberg, L Wechsler, R Bammer, MP Marks, GW Albers
Stroke | Published : 2009
Abstract
Background and Purpose-: Acute ischemic lesions with restricted diffusion can resolve after early recanalization. The impact of superimposedperfusion abnormalities on the fate of acute diffusion lesions is unclear. Methods-: Data were obtained from DEFUSE, a prospective multicenter study of patients treated with IV tPA 3 to 6 hours after stroke onset. Thirty-two patients with baseline diffusion and perfusion lesions and 30 day FLAIR scans were coregistered. The acute diffusion lesion was divided into 3 regions according to the Tmax delay of the superimposed perfusion lesion: normal baseline perfusion; mild-moderately hypoperfused (2 s8 s). The reversal rate was calculated as the percentage o..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
The funding for this study was provided by National Institutes of Health (NIH) grants RO1 NS39325, Principal Investigator, Gregory W. Albers; K24 NS044848, Principal Investigator, Gregory W. Albers; and K23 NS051372, Principal Investigator Maarten G. Lansberg. tPA was supplied at no charge by Genentech (U.S. and Canada sites) and Boehringer Ingelheim (Belgium site). Neither Genentech, Boehringer Ingelheim, nor the NIH played a role in the design and the conduct of the study; collection, management, analysis, and interpretation of the data; or preparation or approval of the manuscript.