Journal article
Optimal tmax threshold for predicting penumbral tissue in acute stroke
JM Olivot, M Mlynash, VN Thijs, S Kemp, MG Lansberg, L Wechsler, R Bammer, MP Marks, GW Albers
Stroke | Published : 2009
Abstract
Background and Purpose-We sought to assess whether the volume of the ischemic penumbra can be estimated more accurately by altering the threshold selected for defining perfusion-weighting imaging (PWI) lesions. Methods-DEFUSE is a multicenter study in which consecutive acute stroke patients were treated with intravenous tissue-type plasminogen activator 3 to 6 hours after stroke onset. Magnetic resonance imaging scans were obtained before, 3 to 6 hours after, and 30 days after treatment. Baseline and posttreatment PWI volumes were defined according to increasing Tmax delay thresholds (>2, >4, >6, and >8 seconds). Penumbra salvage was defined as the difference between the baseline PWI lesion ..
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Awarded by National Institute of Neurological Disorders and Stroke
Funding Acknowledgements
Funding for this study was provided by National Institutes of Health (NIH) grants RO1 NS39325, Principal Investigator G. W. A.; M. P. M., M. M.; K24 NS044848, Principal Investigator G. W. A.; and K23 NS051372, Principal Investigator M. G. L. tPA was supplied at no charge by Genentech (US and Canadian sites) and Boehringer Ingelheim (Belgian site). Genentech, Boehringer Ingelheim, nor the NIH played a role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation or approval of the manuscript.