Journal article
Ectopic bone formation by mesenchymal stem cells derived from human term placenta and the decidua
GD Kusuma, D Menicanin, S Gronthos, U Manuelpillai, MH Abumaree, MD Pertile, SP Brennecke, B Kalionis
Plos One | Published : 2015
Open access
Abstract
Mesenchymal stem cells (MSCs) are one of the most attractive cell types for cell-based bone tissue repair applications. Fetal-derived MSCs and maternal-derived MSCs have been isolated from chorionic villi of human term placenta and the decidua basalis attached to the placenta following delivery, respectively. Chorionic-derived MSCs (CMSCs) and decidua-derived MSCs (DMSCs) generated in this study met the MSCs criteria set by International Society of Cellular Therapy. These criteria include: (i) adherence to plastic; (ii) >90% expression of CD73, CD105, CD90, CD146, CD44 and CD166 combined with <5% expression of CD45, CD19 and HLA-DR; and (iii) ability to differentiate into osteogenic, adipoge..
View full abstractGrants
Awarded by King Abdullah International Medical Research Centre
Funding Acknowledgements
BK and SPB were supported by grants from King Abdullah International Medical Research Centre (Grant No. RC08/114) and the Royal Women's Hospital Foundation. GK was supported by Australian Postgraduate Award and an Australian Stem Cell Centre Postgraduate Scholarship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.