Journal article

THYROTROPIN (TSH) BINDING-SITES ON YERSINIA-ENTEROCOLITICA RECOGNIZED BY IMMUNOGLOBULINS FROM HUMANS WITH GRAVES-DISEASE

P HEYMA, LC HARRISON, R ROBINSBROWNE

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | BLACKWELL SCIENCE LTD | Published : 1986

Abstract

Antibodies against the gram negative enteric bacterium Yersinia enterocolitica have been found in a high proportion of persons with autoimmune thyroid disorders, especially in those with Graves' disease or hyperthyroidism (Shenkman & Bottone, 1981). There is strong evidence that Graves' disease is caused by receptor autoantibodies which mimic the bioeffects of thyroid stimulating hormone (TSH) on the thyroid (Manley, Knight & Adams, 1982). Recently, saturable binding sites for TSH were demonstrated in Y. enterocolitica under non-physiological conditions (Weiss et al., 1983). We have characterized TSH binding sites on Y. enterocolitica under physiological conditions and studied their interact..

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