Journal article

Bacterial vectors: why have they failed to deliver

R Strugnell, C Simmons, O Wijburg, T Uren, D Drew, S Dunstan

AUSTRALASIAN BIOTECHNOLOGY | AUSTRALIAN BIOTECHNOLOGY ASSOC LTD | Published : 1998

Abstract

Bacterial vaccine vectors have been studied experimentally for over twenty years yet there are no vector-based vaccines in commercial human or veterinary use today. The absence of human vector-based vaccines is probably due to problems associated with testing human vaccines, and a lack of funds to support vaccines for use in developing countries. Vector-based veterinary vaccines are currently not competitive with combination adjuvanted vaccines but may have a niche under certain circumstances. The future of vaccine vectors may lie in the delivery of DNA vaccines.