SALMONELLA-TYPHIMURIUM DISPLAYS NORMAL INVASION OF MICE WITH DEFECTIVE EPIDERMAL GROWTH-FACTOR RECEPTORS
A MCNEIL, SJ DUNSTAN, S CLARK, RA STRUGNELL
INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 1995
The role of the epidermal growth factor (EGF) receptor in cell invasion by Salmonella typhimurium was examined in vitro and in vivo by using waved-2 mice which express an EGF receptor with reduced kinase activity. S. typhimurium invaded fibroblasts from waved-2 mice as efficiently as fibroblasts from wild-type control animals. In vivo, S. typhimurium both invaded the gastrointestinal tract and penetrated through to the spleen of waved-2 mice. Our studies suggest that the EGF receptor has only a limited role, if any, in cell invasion by S. typhimurium.