Journal article

Magnetoencephalography signals are influenced by skull defects

S Lau, L Flemming, J Haueisen



OBJECTIVE: Magnetoencephalography (MEG) signals had previously been hypothesized to have negligible sensitivity to skull defects. The objective is to experimentally investigate the influence of conducting skull defects on MEG and EEG signals. METHODS: A miniaturized electric dipole was implanted in vivo into rabbit brains. Simultaneous recording using 64-channel EEG and 16-channel MEG was conducted, first above the intact skull and then above a skull defect. Skull defects were filled with agar gels, which had been formulated to have tissue-like homogeneous conductivities. The dipole was moved beneath the skull defects, and measurements were taken at regularly spaced points. RESULTS: The EEG ..

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Awarded by German Research Foundation

Awarded by Australian National Health and Medical Research Council

Awarded by German Academic Exchange Service

Funding Acknowledgements

This work was supported by the German Research Foundation [Ha2899/14-1]; the Australian National Health and Medical Research Council [558425]; the German Academic Exchange Service [D/08/13928, 54388947]; and the Australian Group of Eight. We wish to thank Stefan Clauss, Hannes Nowak, Ralph Huonker, Frank Giessler, Daniel Gullmar, Eric Lopatta, Simon Vogrin, Levin Kuhlmann, David Grayden, and Mark Cook for their support. We thank the Research Workshop of the Jena University Hospital for the production of the high-density EEG array, the physical dipole model, and the stereotactic device.