Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study
Baemisla Shiek Ahmad, John D Wark, Sandra J Petty, Terence J O'Brien, Alexandra Gorelik, Phillip N Sambrook, Keith D Hill
EPILEPSIA | WILEY | Published : 2015
OBJECTIVE: To investigate cross-sectional and longitudinal differences in static and dynamic standing balance measures and lower limb muscle strength in patients who are treated chronically with antiepileptic drugs (AEDs). METHODS: Twenty-six AED exposure-discordant same-gender twin and sibling pairs were studied. Clinical and laboratory balance examinations were conducted twice, separated by at least 1 year. The mean within-pair differences in balance measures were calculated cross-sectionally at baseline and follow-up, and longitudinally. RESULTS: No significant mean within-pair difference was found at baseline in age (44 years), weight, and height (p > 0.05). Between study assessments, th..View full abstract
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Awarded by NHMRC
This research was funded by the Department of Medicine, University of Melbourne and in part supported by an NHMRC Project Grant (400089). Dr. Shiek Ahmad obtained financial support throughout her PhD from the University of Malaya and the Malaysian Ministry of Higher Education. Professors Wark and O'Brien received research support largely from UCB Pharma, for studies unrelated to this research. Professor Hill, Ms. Gorelik, and Dr. Petty report no disclosures. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.