Journal article

The burgeoning family of unconventional T cells

Dale I Godfrey, Adam P Uldrich, James McCluskey, Jamie Rossjohn, D Branch Moody

NATURE IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2015

Abstract

While most studies of T lymphocytes have focused on T cells reactive to complexes of peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do not fit this paradigm. These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells. Collectively, these T cells are considered 'unconventional', in part because they can recognize lipids, small-molecule metabolites and specially modified peptides. Unlike MHC-reactive T cells, these apparently disparate T cell types generally show simplified patterns of T cell antigen receptor (TCR) expression, rapid effector responses and 'public..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Awarded by National Institute of Allergy and Infectious Diseases


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Funding Acknowledgements

We thank M. Sugita and N. LaGruta for discussions. Supported by the National Health and Medical Research Council of Australia (1013667 and 1063587; 1020770 to DIG.; and AF50 to JR.), the Australian Research Council (CE140100011 and LE110100106; and FT140100278 to A.P.U.), Cancer Council Victoria, the Bill and Melinda Gates Foundation Vaccine Accelerator, and the National Institute of Allergy and Infectious Diseases (AI049313, AR048632 and U19111224).