The burgeoning family of unconventional T cells

DI Godfrey; AP Uldrich; J Mccluskey; J Rossjohn; DB Moody

Journal article

The burgeoning family of unconventional T cells

DI Godfrey, AP Uldrich, J Mccluskey, J Rossjohn, DB Moody

Nature Immunology | NATURE PUBLISHING GROUP | Published : 2015

DOI: 10.1038/ni.3298

Abstract

While most studies of T lymphocytes have focused on T cells reactive to complexes of peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do not fit this paradigm. These include CD1-restricted T cells, MR1-restricted mucosal associated invariant T cells (MAIT cells), MHC class Ib-reactive T cells, and γδ T cells. Collectively, these T cells are considered 'unconventional', in part because they can recognize lipids, small-molecule metabolites and specially modified peptides. Unlike MHC-reactive T cells, these apparently disparate T cell types generally show simplified patterns of T cell antigen receptor (TCR) expression, rapid effector responses and 'public..

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University of Melbourne Researchers

Dale Godfrey Author

Adam Uldrich Author

McCluskey James Author

Jamie Rossjohn Author

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Grants

Awarded by National Institute of Allergy and Infectious Diseases

Funding Acknowledgements

We thank M. Sugita and N. LaGruta for discussions. Supported by the National Health and Medical Research Council of Australia (1013667 and 1063587; 1020770 to DIG.; and AF50 to JR.), the Australian Research Council (CE140100011 and LE110100106; and FT140100278 to A.P.U.), Cancer Council Victoria, the Bill and Melinda Gates Foundation Vaccine Accelerator, and the National Institute of Allergy and Infectious Diseases (AI049313, AR048632 and U19111224).