Journal article
Malignancy risk in Australian rheumatoid arthritis patients treated with anti-tumour necrosis factor therapy: analysis of the Australian Rheumatology Association Database (ARAD) prospective cohort study
R Buchbinder, S Van Doornum, M Staples, M Lassere, L March
BMC Musculoskeletal Disorders | Published : 2015
Abstract
Background: Malignancy risk with tumour necrosis factor inhibitor (TNFi) therapy remains unclear. Our primary aim was to assess malignancy risk with TNFi therapy in a cohort of Australian patients with rheumatoid arthritis (RA). We also assessed risk in a biologic-naïve group. Methods: Demographic data of all RA patients enrolled in the Australian Rheumatology Association Database before 25 October 2010 were matched to national cancer records in July 2010 (linkage complete to 2007). Verified self-reported malignancies occurring between 1 January 2008 and 25 October 2010 were also included in the analysis. Standardised incidence ratios (SIRs) were used to compare malignancy incidence in biolo..
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Awarded by Roche
Funding Acknowledgements
ARAD has received support from the Commonwealth Government of Australia National Health & Medical Research Council (NHMRC) Enabling Grant (ID 384330), Monash University, the Australian Rheumatology Association, Abbott Australia, Pfizer Australia, Janssen Australia, Sanofi Aventis, Amgen, Wyeth, Schering-Plough and Roche. This analysis was supported by an Arthritis Australia grant-in-aid and a University of Melbourne grant-in-aid. RB is supported by an Australian NHMRC Senior Principal Research Fellowship.