Journal article

Effects of ranibizumab on TGF-beta 1 and TGF-beta 2 production by human Tenon's fibroblasts: An in vitro study

Siti Munirah Md Noh, Siti H Sheikh Abdul Kadir, Jonathan G Crowston, Visvaraja Subrayan, Sushil Vasudevan

Molecular Vision | MOLECULAR VISION | Published : 2015

Abstract

PURPOSE: Inhibiting exaggerated wound healing responses, which are primarily mediated by human Tenon's fibroblast (HTF) migration and proliferation, has become the major determining factor for a successful trabeculectomy. Antivascular endothelial growth factor (anti-VEGF) has showed promising results as a potential antifibrotic candidate for use concurrently in trabeculectomy. Preliminary cohort studies have revealed improved bleb morphology following trabeculectomy augmented with ranibizumab. However, the effects on HTFs remain unclear. This study was conducted to understand the effects of ranibizumab on transforming growth factor (TGF)-β1 and transforming growth factor (TGF)-β2 expression ..

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