Journal article
Measurement of systemic mitochondrial function in advanced Primary Open-Angle Glaucoma and leber hereditary optic neuropathy
NJ Van Bergen, JG Crowston, JE Craig, KP Burdon, LS Kearns, S Sharma, AW Hewitt, DA Mackey, IA Trounce
Plos One | Published : 2015
Open access
Abstract
Primary Open Angle Glaucoma (POAG) is a common neurodegenerative disease characterized by the selective and gradual loss of retinal ganglion cells (RGCs). Aging and increased intraocular pressure (IOP) are glaucoma risk factors; nevertheless patients deteriorate at all levels of IOP, implying other causative factors. Recent evidence presents mitochondrial oxidative phosphorylation (OXPHOS) complex-I impairments in POAG. Leber Hereditary Optic Neuropathy (LHON) patients suffer specific and rapid loss of RGCs, predominantly in young adult males, due to complex-I mutations in the mitochondrial genome. This study directly compares the degree of OXPHOS impairment in POAG and LHON patients, testin..
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Awarded by National Science Foundation
Funding Acknowledgements
This study was supported by the following funding sources: Ophthalmic Research Institute of Australia, Glaucoma Australia, University of Melbourne Early Career Grant, Henry Greenfield Research Fund, Dorothy Adele Edols Trust, Wagstaff Fellowship, National Health and Medical Research Council (#529915, #529923, #590200, #590225, #1061472). CERA receives operational infrastructure support from the Victorian Government.