Journal article

Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

Vanessa L Cropley, Cali E Bartholomeusz, Peter Wu, Stephen J Wood, Tina Proffitt, Warrick J Brewer, Patricia M Desmond, Dennis Velakoulis, Christos Pantelis

Psychiatry Research | ELSEVIER IRELAND LTD | Published : 2015

Abstract

Abnormalities of orbitofrontal cortex (OFC) pattern type distribution have been associated with schizophrenia-spectrum disorders. We investigated OFC pattern type in a large sample of chronic schizophrenia patients and healthy controls. We found an increased frequency of Type II but no difference in Type I or III folding pattern in the schizophrenia group in comparison to controls. Further large studies are required to investigate the diagnostic specificity of altered OFC pattern type and to confirm the distribution of pattern type in the normal population.

Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NARSAD Young Investigator Award


Awarded by NHMRC


Awarded by Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award


Funding Acknowledgements

Dr V.L. Cropley was supported by a National Health and Medical Research Council (NHMRC) Fellowship (628880) and a NARSAD Young Investigator Award (21660). Prof C. Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (18722). Prof S.J. Wood was supported by a NHMRC Clinical Career Developmental Award (359223) and a NARSAD Young Investigator Award. A/Prof W.J. Brewer was supported by a NHMRC Career Development Award (454792) and the Colonial Foundation.