The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice
Santiago Zelenay, Anna M Keller, Paul G Whitney, Barbara U Schraml, Safia Deddouche, Neil C Rogers, Oliver Schulz, David Sancho, Caetano Reis e Sousa
JOURNAL OF CLINICAL INVESTIGATION | AMER SOC CLINICAL INVESTIGATION INC | Published : 2012
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Awarded by Cancer Research UK
Work in the C. Reis e Sousa laboratory is funded by Cancer Research UK and a prize from Fondation Bettencourt-Schueller. S. Zelenay, A.M. Keller, and B.U. Schraml were supported by EMBO long-term fellowships and by a Marie Curie Intra-European Fellowship to S. Zelenay. P.G. Whitney was supported by an Overseas Biomedical Fellowship from the National Health and Medical Research Council of Australia. D. Sancho is a recipient of a Ramon y Cajal fellowship from the Spanish Ministry of Innovation and Science. We thank Gordon Brown for RAW264.7 macrophages expressing the human DNGR-1/mouse Dectin-1 chimeric receptor and Philip East for microarray analysis. We are grateful to members of the Cancer Research UK. Immunobiology Laboratory for assistance and helpful discussions.