Journal article
Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C
DD Cyr, JE Lucas, JW Thompson, K Patel, PJ Clark, A Thompson, HL Tillmann, JG McHutchison, MA Moseley, JJ McCarthy
Plos One | Published : 2011
Abstract
Introduction: Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous clearance and treatment response to pegIFN/RBV in chronic hepatitis C (CHC) patients. The molecular consequences of this genetic variation are unknown. To gain further insight into IL28B function we assessed the association of rs12979860 with expression of protein quantitative traits (pQTL analysis) generated using open-platform proteomics in serum from patients. Methods: 41 patients with genotype 1 chronic hepatitis C infection from the Duke Liver Clinic were genotyped for rs12979860. Proteomic profiles were generated by LC-MS/MS analysis following imm..
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Awarded by National Center for Research Resources
Funding Acknowledgements
This study was funded by a generous grant from the David H Murdock Institute for Business and Culture via the M.U.R.D.O.C.K. Study and NIH CTSA award 1 UL1 RR024128-01 to Duke University (Dr. Robert Califf, Principal Investigator). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received for this study.