Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C.

Derek D Cyr; Joseph E Lucas; J Will Thompson; Keyur Patel; Paul J Clark; Alexander Thompson; Hans L Tillmann; John G McHutchison; M Arthur Moseley; Jeanette J McCarthy

Journal article

Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C.

Derek D Cyr, Joseph E Lucas, J Will Thompson, Keyur Patel, Paul J Clark, Alexander Thompson, Hans L Tillmann, John G McHutchison, M Arthur Moseley, Jeanette J McCarthy

PLoS One | Published : 2011

DOI: 10.1371/journal.pone.0021854

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Abstract

INTRODUCTION: Polymorphisms near the IL28B gene (e.g. rs12979860) encoding interferon λ3 have recently been associated with both spontaneous clearance and treatment response to pegIFN/RBV in chronic hepatitis C (CHC) patients. The molecular consequences of this genetic variation are unknown. To gain further insight into IL28B function we assessed the association of rs12979860 with expression of protein quantitative traits (pQTL analysis) generated using open-platform proteomics in serum from patients. METHODS: 41 patients with genotype 1 chronic hepatitis C infection from the Duke Liver Clinic were genotyped for rs12979860. Proteomic profiles were generated by LC-MS/MS analysis following imm..

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