Endovascular revascularization results in IMS III: intracranial ICA and M1 occlusions
Thomas A Tomsick, Sharon D Yeatts, David S Liebeskind, Janice Carrozzella, Lydia Foster, Mayank Goyal, Ruediger von Kummer, Michael D Hill, Andrew M Demchuk, Tudor Jovin, Bernard Yan, Osama O Zaidat, Wouter Schonewille, Stefan Engelter, Renee Martin, Pooja Khatri, Judith Spilker, Yuko Y Palesch, Joseph P Broderick
Journal of NeuroInterventional Surgery | BMJ PUBLISHING GROUP | Published : 2015
BACKGROUND: Interventional Management of Stroke III did not show that combining IV recombinant tissue plasminogen activator (rt-PA) with endovascular therapies (EVTs) is better than IV rt-PA alone. OBJECTIVE: To report efficacy and safety results for EVT of intracranial internal carotid artery (ICA) and middle cerebral artery trunk (M1) occlusion. METHODS: Five revascularization methods for persistent occlusions after IV rt-PA treatment were evaluated for prespecified primary and secondary endpoints, after accounting for differences in key baselines variables using propensity scores. Revascularization was scored using the arterial occlusive lesion (AOL) and the modified Thrombolysis in Cereb..View full abstract
Awarded by National Institute of Neurologic Disease and Stoke
Awarded by Alberta Innovates
The study was supported by the National Institue of Health and National Institute of Neurologic Disease and Stoke (UC U01NS052220, MUSC U01NS054630, and U01NS077304), and by Genentech, EKOS, Concentric Medical, Cordis Neurovascular, and Boehringer Ingelheim.