Corticotropin effects on blood pressure and fluid and electrolyte homeostasis in five strains of rats

Abstract

The hemodynamic and metabolic effects of 11 days of sham (saline) and corticotropin injection were examined in five different strains of rats: Sprague- Dawley, spontaneously hypertensive (SHR), Wis- tar-Kyoto (WKY), Brattleboro, and Long Evans. Corticotropin significantly increased systolic blood pressure (SBP) compared with sham injection in all strains: Final SBP in Sprague-Dawley was 108 ±5 mm Hg corticotropin, 94 ± 4 mm Hg sham; SHR 146 ± 6 mm Hg corticotropin, 141 ± 3 mm Hg sham; WKY 117 ± 3 mm Hg corticotropin, 103 ± 3 mm Hg sham; Brattleboro 108 ± 5 mm Hg corticotropin, 93 ± 2 mm Hg sham; and Long Evans 103 ± 5 mm Hg corticotropin, 90 ± 4 mm Hg sham (P `.001). Corticotropin also produ..