Journal article

Old tracer for a new purpose: potential role for Tc-99m-2-methoxyisobutylisonitrile (Tc-99m-MIBI) in renal transplant care

Sabina Dizdarevic, Mark Aplin, Melanie J Newport, Nicola Ryan, Stephen Holt, Stephanie Goubet, Lawrence Goldberg, Kenneth A Miles, A Michael Peters

Nuclear Medicine Communications | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014

Abstract

AIM: Calcineurin inhibitors are substrates for P-glycoprotein (P-gp), the expression of which is associated with ABCB1 C3435T polymorphism. Individual P-gp response to calcineurin inhibitor may be linked to nephrotoxicity or rejection. Tc-2-Methoxyisobutylisonitrile (Tc-MIBI) is also a P-gp substrate. The aim of this study, therefore, was to determine Tc-MIBI organ kinetics and compare them with ABCB1 genotype with a view to replacing Tc-mercaptoacetyltriglycine (Tc-MAG3) with Tc-MIBI in renal transplant care. METHODS: Thirty prospective donors (13 male) were imaged for 20 min after administration of Tc-MIBI (400 MBq) intravenously. Posterior images of the abdomen were acquired at 30 and 120..

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