Does a Patent Foramen Ovale Influence Cognitive Function in Dialysis Patients?
Sudhakar George, Stephen Holt, Nick Medford, David Hildick-Smith
NEPHRON CLINICAL PRACTICE | KARGER | Published : 2013
BACKGROUND: Patients with chronic kidney disease on dialysis treatment have poorer cognitive function than age- and sex-matched controls. One proposed mechanism is cerebral microembolisation due to material from the dialysis circuit crossing a patent foramen ovale (PFO). METHODS: Cognitive testing was carried out in haemodialysis (HD) patients and peritoneal dialysis (PD) patients. Transthoracic echocardiography was used to identify PFO. Follow-up testing 1 year later enabled comparison of cognitive decline between patients with and without a PFO, and between those undergoing different dialysis modalities. RESULTS: 80 patients (aged 60.4 ± 15.0 years) were recruited (51 HD patients and 29 PD..View full abstract