Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in patients with pre-dialysis CKD
Edward R Smith, Martin L Ford, Laurie A Tomlinson, Chakravarthi Rajkumar, Lawrence P McMahon, Stephen G Holt
Nephrology Dialysis Transplantation | OXFORD UNIV PRESS | Published : 2012
BACKGROUND: Vascular stiffening occurs in normal ageing and is accelerated in chronic kidney disease (CKD). Vascular calcification contributes to this stiffening and to the high incidence of vascular morbidity and mortality in this population. A network of inhibitors work in concert to reduce mineralization risk in extra-osseous tissue. Fetuin-A is an important systemic inhibitor of ectopic calcification. A fraction of the total circulating fetuin-A interacts with mineral ions to form stable colloidal complexes, calciprotein particles (CPP), preventing deposition. We sought to assess whether CPP fetuin-A levels were associated with procalcific factors and aortic stiffness in a cohort of pati..View full abstract
This study was supported by the Department of Renal Medicine and the Clinical Investigation Research Unit at BSUH NHS Trust.