Elastin Degradation Is Associated With Progressive Aortic Stiffening and All-Cause Mortality in Predialysis Chronic Kidney Disease
Edward R Smith, Laurie A Tomlinson, Martin L Ford, Lawrence P McMahon, Chakravarthi Rajkumar, Stephen G Holt
Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2012
In the large conduit arteries, elastin is important in maintaining vascular compliance. Studies in animal models suggest that elastin degradation may promote arteriosclerotic vascular changes. There is already a well-established link between aortic stiffening and mortality in the general population and in patients undergoing dialysis. Elastin degradation is mediated by several proteases, including matrix metalloproteinase 2 and cathepsin S. Elastin turnover may be inferred by measuring serum levels of elastin-derived peptides. We analyzed the serum concentration of these biomarkers, their endogenous inhibitors, and aortic pulse wave velocity in 200 patients with stages 3 and 4 chronic kidney..View full abstract
We gratefully acknowledge the support from the Sussex Kidney Unit and the Clinical Investigation and Research Unit, Brighton and Sussex University Hospitals, United Kingdom, and the Department of Renal Medicine, Eastern Health Clinical School, Monash University, Australia.