Journal article

The value of simultaneous measurements of urinary albumin and total protein in proteinuric patients

Edward R Smith, Michael MX Cai, Lawrence P McMahon, David A Wright, Stephen G Holt

Nephrology Dialysis Transplantation | OXFORD UNIV PRESS | Published : 2012

Abstract

BACKGROUND: Proteinuria is a common pathological finding in renal disease. Examining the urinary protein electrophoretic pattern gives clues to the site of origin of the protein. We hypothesized that the type of proteinuria, classified by urine protein electrophoresis and immunofixation (uPEI), may be predicted by simply examining the proportion of higher molecular weight protein (e.g. albumin) in urine total protein content. METHODS: One thousand and eleven patients, whose urine had been sent to the pathology department for uPEI, were analysed for total protein and albumin to creatinine ratio (uPCR and uACR) and the ratio reported as the albumin to total protein ratio (uAPR). In a group of ..

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