Journal article

Spectrum of chronic kidney disease in HIV-infected patients

LJ Campbell, F Ibrahim, M Fisher, SG Holt, BM Hendry, FA Post

HIV Medicine | WILEY | Published : 2009

Abstract

OBJECTIVES: The aim of the study was to investigate the prevalence and aetiology of chronic kidney disease (CKD) and trends in estimated glomerular filtration rate (eGFR) in HIV-infected patients. METHODS: Ascertainment and review of CKD cases among patients attending King's College and Brighton Hospitals, UK were carried out. CKD was defined as eGFR or =3 months. Longitudinal eGFR slopes were produced to examine trends in renal function before, during and after exposure to indinavir (IDV) or tenofovir (TFV). RESULTS: CKD prevalence was 2.4%. While HIV-associated nephropathy accounted for 62% of CKD in black patients, 95% of CKD in white/other patients was associated with diabetes mellitus,..

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Grants

Awarded by GlaxoSmithKline


Funding Acknowledgements

The authors wish to thank Stephen Duffell, Nicky Perry, Anthony Pullin, Richard Shanahan and Elizabeth Tissingh for their assistance with data collection, IT, R&D submission, and/or access to hospital notes.Funding: Funding for this study was obtained from GlaxoSmithKline (grant COL109793 to FAP). The funder was not involved in study design, data analysis or interpretation of the results.Conflict of interest: FAP, SGH, MF and BMH have received research grants or honoraria from Gilead Sciences and GlaxoSmithKline. None of the other authors has a conflict of interest to report.