Spectrum of chronic kidney disease in HIV-infected patients
LJ Campbell, F Ibrahim, M Fisher, SG Holt, BM Hendry, FA Post
HIV Medicine | WILEY | Published : 2009
OBJECTIVES: The aim of the study was to investigate the prevalence and aetiology of chronic kidney disease (CKD) and trends in estimated glomerular filtration rate (eGFR) in HIV-infected patients. METHODS: Ascertainment and review of CKD cases among patients attending King's College and Brighton Hospitals, UK were carried out. CKD was defined as eGFR or =3 months. Longitudinal eGFR slopes were produced to examine trends in renal function before, during and after exposure to indinavir (IDV) or tenofovir (TFV). RESULTS: CKD prevalence was 2.4%. While HIV-associated nephropathy accounted for 62% of CKD in black patients, 95% of CKD in white/other patients was associated with diabetes mellitus,..View full abstract
Awarded by GlaxoSmithKline
The authors wish to thank Stephen Duffell, Nicky Perry, Anthony Pullin, Richard Shanahan and Elizabeth Tissingh for their assistance with data collection, IT, R&D submission, and/or access to hospital notes.Funding: Funding for this study was obtained from GlaxoSmithKline (grant COL109793 to FAP). The funder was not involved in study design, data analysis or interpretation of the results.Conflict of interest: FAP, SGH, MF and BMH have received research grants or honoraria from Gilead Sciences and GlaxoSmithKline. None of the other authors has a conflict of interest to report.