Journal article
A meta-analysis of changes in brain activity in clinical depression
SM Palmer, SG Crewther, LM Carey
Frontiers in Human Neuroscience | Published : 2015
Abstract
Insights into neurobiological mechanisms of depression are increasingly being sought via brain imaging studies. Our aim was to quantitatively summarize overlap and divergence in regions of altered brain activation associated with depression under emotionally valenced compared to cognitively demanding task conditions, and with reference to intrinsic functional connectivity. We hypothesized differences reflective of task demands. A co-ordinate-based meta-analysis technique, activation likelihood estimation, was used to analyze relevant imaging literature. These studies compared brain activity in depressed adults relative to healthy controls during three conditions: (i) emotionally valenced (co..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors would like to acknowledge the Commonwealth Scientific Industrial Research Organisation (CSIRO) preventative Health flagship grant. Leeanne M. Carey was supported by an Australian Research Council Future Fellowship (#FT0992299). Susan M. Palmer is supported in part by the CSIRO preventative Health flagship grant. Leeanne M. Carey and Susan M. Palmer are grateful to the Victorian Government's Operational Infrastructure Support Program for support. Sheila G. Crewther acknowledges the support of NHMRC App10004740. Leeanne M. Carey acknowledges the support of NHMRC grant App1022694. No writing assistance was utilized in the production of this manuscript.