Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production
Hannah EJ Yong, Padma Murthi, May H Wong, Bill Kalionis, Judith E Cartwright, Shaun P Brennecke, Rosemary J Keogh
Pregnancy Hypertension | ELSEVIER SCI LTD | Published : 2015
OBJECTIVES: Activin A, a TGFβ family member, circulates in the maternal blood at increasing concentrations throughout gestation during a healthy pregnancy. The circulating concentration of activin A is further increased in pre-eclampsia (PE), a hypertensive disorder of pregnancy that is marked by systemic maternal vascular endothelial cell dysfunction. The effect of increasing activin A concentrations on the maternal vascular endothelium is unknown. The study aim was to investigate the effect of physiological and pathological activin A concentrations observed in normotensive and PE pregnancies respectively, on vascular endothelial cell function. METHODS AND RESULTS: Immunostaining demonstrat..View full abstract
This study was funded by The Royal Women's Hospital, Melbourne, Australia. H.E.J. Yong was supported by The University of Melbourne's Melbourne International Fee Remission Scholarship and the Felix Meyer Scholarship in Obstetrics and Gynaecology.