Journal article

Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production

Hannah EJ Yong, Padma Murthi, May H Wong, Bill Kalionis, Judith E Cartwright, Shaun P Brennecke, Rosemary J Keogh

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | ELSEVIER SCI LTD | Published : 2015

Abstract

OBJECTIVES: Activin A, a TGFβ family member, circulates in the maternal blood at increasing concentrations throughout gestation during a healthy pregnancy. The circulating concentration of activin A is further increased in pre-eclampsia (PE), a hypertensive disorder of pregnancy that is marked by systemic maternal vascular endothelial cell dysfunction. The effect of increasing activin A concentrations on the maternal vascular endothelium is unknown. The study aim was to investigate the effect of physiological and pathological activin A concentrations observed in normotensive and PE pregnancies respectively, on vascular endothelial cell function. METHODS AND RESULTS: Immunostaining demonstrat..

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