Journal article

An individualized approach to sustained inflation duration at birth improves outcomes in newborn preterm lambs

David G Tingay, Anna Lavizzari, Cornelis EE Zonneveld, Anushi Rajapaksa, Emanuela Zannin, Elizabeth Perkins, Don Black, Magdy Sourial, Raffaele L Dellaca, Fabio Mosca, Andy Adler, Bartlomiej Grychtol, Inez Frerichs, Peter G Davis

American Journal of Physiology - Lung Cellular and Molecular Physiology | AMER PHYSIOLOGICAL SOC | Published : 2015

Abstract

A sustained first inflation (SI) at birth may aid lung liquid clearance and aeration, but the impact of SI duration relative to the volume-response of the lung is poorly understood. We compared three SI strategies: 1) variable duration defined by attaining volume equilibrium using real-time electrical impedance tomography (EIT; SIplat); 2) 30 s beyond equilibrium (SIlong); 3) short 30-s SI (SI30); and 4) positive pressure ventilation without SI (no-SI) on spatiotemporal aeration and ventilation (EIT), gas exchange, lung mechanics, and regional early markers of injury in preterm lambs. Fifty-nine fetal-instrumented lambs were ventilated for 60 min after applying the allocated first inflation ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by National Health and Medical Research Council Clinical Career Development Fellowship


Awarded by Practitioner Fellowship


Funding Acknowledgements

This study is supported by a National Health and Medical Research Council Project Grant 1009287 (Canberra, Australia) and the Victorian Government Operational Infrastructure Support Program. D. G. Tingay is supported by a National Health and Medical Research Council Clinical Career Development Fellowship Grant 1053889. P. G. Davis is supported by a National Health and Medical Research Council Program Grant 606789 and Practitioner Fellowship Grant ID 556600.