Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability
Mohammed Akhter Hossain, Linda M Haugaard-Kedstroem, K Johan Rosengren, Ross AD Bathgate, John D Wade
Organic & Biomolecular Chemistry | ROYAL SOC CHEMISTRY | Published : 2015
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Awarded by National Health & Medical Research Council (NHMRC) of Australia
We thank Mrs Sharon Layfield and Mrs Tania Ferraro for expert technical assistance and Associate Professor Andrea J. Robinson and Dr Bianca van Lierop (Monash University) for providing assistance with the RCM reaction. This work was supported by National Health & Medical Research Council (NHMRC) of Australia Grants (GNT1023321, GNT1023078, and GNT1065481) awarded to M. A. H., J. D. W, K. J. R, and R. A. D. B. Research at The Florey Institute of Neuroscience and Mental Health is supported by the Victorian Government Operational Infrastructure Support Program.