Journal article

Kinetics of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance

Corin Storkey, David I Pattison, Marta T Ignasiak, Carl H Schiesser, Michael J Davies

FREE RADICAL BIOLOGY AND MEDICINE | ELSEVIER SCIENCE INC | Published : 2015

Abstract

Peroxynitrite (the physiological mixture of ONOOH and its anion, ONOO(-)) is a powerful biologically-relevant oxidant capable of oxidizing and damaging a range of important targets including sulfides, thiols, lipids, proteins, carbohydrates and nucleic acids. Excessive production of peroxynitrite is associated with several human pathologies including cardiovascular disease, ischemic-reperfusion injury, circulatory shock, inflammation and neurodegeneration. This study demonstrates that low-molecular-mass selenols (RSeH), selenides (RSeR') and to a lesser extent diselenides (RSeSeR') react with peroxynitrite with high rate constants. Low molecular mass selenols react particularly rapidly with ..

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Grants

Awarded by Australian Research Council


Awarded by National Heart Foundation of Australia


Awarded by Novo Nordisk Foundation


Awarded by Novo Nordisk Fonden


Funding Acknowledgements

We are grateful to the Australian Research Council (through the Centres of Excellence Scheme, CE0561607, and Discovery Programs DP0988311), the National Heart Foundation of Australia (Grants-in-aids G0954313 and G11S 5811) and the Novo Nordisk Foundation (Laureate Research Grant NNF130C0004294 to MJD) for financial support. We thank Professors Vimal K. Jain and K. Indira Priyadarsini of Bhabha Atomic Research Centre, Mumbai (India), for providing 3,3'-diselenodipropionic acid.