Journal article
Early high flow nasal cannula therapy in bronchiolitis, a prospective randomised control trial (protocol): A Paediatric Acute Respiratory Intervention Study (PARIS)
D Franklin, S Dalziel, LJ Schlapbach, FE Babl, E Oakley, SS Craig, JS Furyk, J Neutze, K Sinn, JA Whitty, K Gibbons, J Fraser, A Schibler, J Gavranich, S Moloney, P Shirkhedkar, T Hurley, M Radcliffe, V Kapoor, D McMaster Show all
BMC Pediatrics | Published : 2015
Open access
Abstract
Background: Bronchiolitis imposes the largest health care burden on non-elective paediatric hospital admissions worldwide, with up to 15 % of cases requiring admission to intensive care. A number of previous studies have failed to show benefit of pharmaceutical treatment in respect to length of stay, reduction in PICU admission rates or intubation frequency. The early use of non-invasive respiratory support devices in less intensive scenarios to facilitate earlier respiratory support may have an impact on outcome by avoiding progression of the disease process. High Flow Nasal Cannula (HFNC) therapy has emerged as a new method to provide humidified air flow to deliver a non-invasive form of p..
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Awarded by National Science Foundation
Funding Acknowledgements
We would like to thank participating families, emergency and paediatric department staff and the site research assistants. The study is funded by a project grant from the National Health and Medical Research Council (NHMRC, APP1081736), Canberra, Australia, and Queensland Emergency Medical Research Fund (QEMRF), Brisbane, Australia. Regional site funding was obtained for Ipswich Hospital from the Ipswich Hospital Foundation and the Gold Coast University Hospital (GCUH) from the GCUH Foundation. AS received a three year research fellowship from the Queensland Health Department, Australia. PREDICT sites were supported by a National Health and Medical Research Council Centre of Research Excellence grant for paediatric emergency medicine (GNT1058560). Victorian sites received infrastructure support from the Victorian Government's Infrastructure Support Program, Melbourne, Australia. FEB was part funded by a Royal Children's Hospital Foundation grant, Melbourne, Australia. SRD was part funded by a grant from the Health Research Council of New Zealand (HRC), Auckland, New Zealand.