Journal article
Injectable phenytoin loaded polymeric microspheres for the control of temporal lobe epilepsy in rats
JL Jiang, Z Yue, SH Bauquier, A Lai, Y Chen, KJ McLean, AJ Halliday, Y Sui, S Moulton, GG Wallace, MJ Cook
Restorative Neurology and Neuroscience | IOS PRESS | Published : 2015
DOI: 10.3233/RNN-150520
Abstract
Purpose: Epilepsy is a prevalent neurological disorder with a high frequency of drug resistance. While significant advancements have been made in drug delivery systems to overcome anti-epileptic drug resistance, efficacies of materials in biological systems have been poorly studied. The purpose of the study was to evaluate the anti-epileptic effects of injectable poly(epsiloncaprolactone) (PCL) microspheres for controlled release of an anticonvulsant, phenytoin (PHT), in an animal model of epilepsy. Methods: PHT-PCL and Blank-PCL microspheres formulated using an oil-in-water (O/W) emulsion solvent evaporation method were evaluated for particle size, encapsulation efficiency, surface morpholo..
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Funding Acknowledgements
The authors thank the Australian Research Council and National Health & Medical Research Council for continuing financial support. The authors gratefully acknowledge the sponsorship of the Victorian Government through its Science Technology and Innovation Initiative administered by the Department of Industry, Innovation and Regional Development. GGW thanks the ARC for his Laureate Fellowships. The authors also acknowledge use of the facilities and the assistance of Mr. Tony Romeo at the UOW Electron Microscopy Centre. The authors are grateful for access to materials synthesis and characterization equipment made available through the Australian National Fabrication Facility (ANFF).