Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors
Dorothee Heck, Sebastian Wortmann, Luitgard Kraus, Cristina L Ronchi, Richard O Sinnott, Martin Fassnacht, Silviu Sbiera
Hormones & Cancer | SPRINGER | Published : 2015
Angiogenesis is essential for tumor growth and metastasis. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic factor predominantly expressed in steroidogenic organs like the adrenal gland, ovary, testes, and placenta. EG-VEGF has antiapoptotic, mitogenic, and chemoattractive properties mediated via the two G protein-coupled receptors prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2). We investigated the expression of EG-VEGF and its receptors in a large number of normal adrenal glands (NAG), adrenocortical adenomas (ACA), and carcinomas (ACC) using real-time PCR (NAG, n = 12; ACA, n = 24; and ACC, n = 30) and immunohistochemistry (NAG, n = 9..View full abstract
Awarded by Deutsche Forschungsgemeinschaft
Awarded by Wilhelm Sander-Stiftung
Awarded by Bayer AG
This study was supported by grants from the Deutsche Forschungsgemeinschaft (grant FA 466/4-1 to M.F.), the Wilhelm Sander-Stiftung (grant 2012.095.2 to M.F.), and the Bayer AG (Grants4targets 2014-03-1075 to S.S.).