Journal article

How Is the Number of Primordial Follicles in the Ovarian Reserve Established?

John K Findlay, Karla J Hutt, Martha Hickey, Richard A Anderson

Biology of Reproduction | OXFORD UNIV PRESS INC | Published : 2015


The number of primordial follicles in the ovarian reserve is an important determinant of the length of the ovarian lifespan, and therefore the fertility of an individual. This reserve contains all of the oocytes potentially available for fertilization throughout the fertile lifespan. The maximum number is set during pregnancy or just after birth in most mammalian species; current evidence does not support neofolliculogenesis after the ovarian reserve is established, although this is increasingly being reexamined. Under physiological circumstances, this number will be influenced by the number of primordial germ cells initially specified in the epiblast of the developing embryo, their prolifer..

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Awarded by National Health and Medical Research Council (NHMRC) Career Development Fellowship

Awarded by NHMRC Practitioner Fellowship

Awarded by U.K. Medical Research Council

Awarded by Medical Research Council

Funding Acknowledgements

The support of National Health and Medical Research Council (NHMRC) Career Development Fellowship no. 1050130 to K.J.H., NHMRC Practitioner Fellowship no. 1058935 to M.H., and U.K. Medical Research Council no. G1100357/1 to R.A.A. are gratefully acknowledged. This work is also supported by the State Government Operational Infrastructure Support (OIS) Program.