Depression, immune function, and early adrenarche in children
Faustina M Delany, Michelle L Byrne, Sarah Whittle, Julian G Simmons, Craig Olsson, Lisa K Mundy, George C Patton, Nicholas B Allen
PSYCHONEUROENDOCRINOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Despite consistent findings of an association between depression and immunity in adult and adolescent populations, little is known about the nature of this relationship at earlier ages. Studies of children have yielded mixed results, suggesting methodological confounds and/or the presence of significant moderating factors. Timing of adrenarche, the first phase of puberty that occurs during late childhood, is a plausible moderator of the depression-immunity relationship in late childhood due to its associations with both the immune system and psychological wellbeing. We hypothesized that: (1) a depression-immunity association exists in children, (2) this association is moderated by adrenarche..View full abstract
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Awarded by Australian Research Council
Awarded by National Health and Medial Council (NHMRC)
This work was supported by the Australian Research Council (Discovery Project grant: DP120101402), and the National Health and Medial Council (NHMRC; Career Development Fellowship ID 1007,716 to SW). MCRI research is supported by the Victorian Government's Operational Infrastructure Program.