Journal article

The pathway not taken: understanding 'omics data in the perinatal context

Andrea G Edlow, Donna K Slonim, Heather C Wick, Lisa Hui, Diana W Bianchi

American Journal of Obstetrics and Gynecology | MOSBY-ELSEVIER | Published : 2015

Abstract

OBJECTIVE: 'Omics analysis of large datasets has an increasingly important role in perinatal research, but understanding gene expression analyses in the fetal context remains a challenge. We compared the interpretation provided by a widely used systems biology resource (ingenuity pathway analysis [IPA]) with that from gene set enrichment analysis (GSEA) with functional annotation curated specifically for the fetus (Developmental FunctionaL Annotation at Tufts [DFLAT]). STUDY DESIGN: Using amniotic fluid supernatant transcriptome datasets previously produced by our group, we analyzed 3 different developmental perturbations: aneuploidy (Trisomy 21 [T21]), hemodynamic (twin-twin transfusion syn..

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