Journal article

Antenatal Noninvasive DNA Testing: Clinical Experience and Impact

Millie A Ferres, Lisa Hui, Diana W Bianchi

American Journal of Perinatology | THIEME MEDICAL PUBL INC | Published : 2014


BACKGROUND: Nearly two decades ago, the discovery of circulating cell-free fetal DNA in maternal blood created a paradigm shift in prenatal testing. Recent advances in DNA sequencing technology have facilitated the rapid translation of DNA-based testing into clinical antenatal care. CONTENT: In this review, we summarize the technical approaches and current clinical applications of noninvasive testing using cell-free DNA in maternal plasma. We discuss the impact of these tests on clinical care, outline proposed integration models, and suggest future directions for the field. SUMMARY: The use of cell-free DNA in maternal blood for the detection of fetal rhesus D antigen status, fetal sex, and ..

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