Journal article

Maternal Obesity Affects Fetal Neurodevelopmental and Metabolic Gene Expression: A Pilot Study

Andrea G Edlow, Neeta L Vora, Lisa Hui, Heather C Wick, Janet M Cowan, Diana W Bianchi

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014

Abstract

OBJECTIVE: One in three pregnant women in the United States is obese. Their offspring are at increased risk for neurodevelopmental and metabolic morbidity. Underlying molecular mechanisms are poorly understood. We performed a global gene expression analysis of mid-trimester amniotic fluid cell-free fetal RNA in obese versus lean pregnant women. METHODS: This prospective pilot study included eight obese (BMI≥30) and eight lean (BMI<25) women undergoing clinically indicated mid-trimester genetic amniocentesis. Subjects were matched for gestational age and fetal sex. Fetuses with abnormal karyotype or structural anomalies were excluded. Cell-free fetal RNA was extracted from amniotic fluid and ..

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Grants

Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Funding Acknowledgements

This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awards R01 HD42053-10 and R01 HD058880. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.