Maternal Obesity Affects Fetal Neurodevelopmental and Metabolic Gene Expression: A Pilot Study
Andrea G Edlow, Neeta L Vora, Lisa Hui, Heather C Wick, Janet M Cowan, Diana W Bianchi
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014
OBJECTIVE: One in three pregnant women in the United States is obese. Their offspring are at increased risk for neurodevelopmental and metabolic morbidity. Underlying molecular mechanisms are poorly understood. We performed a global gene expression analysis of mid-trimester amniotic fluid cell-free fetal RNA in obese versus lean pregnant women. METHODS: This prospective pilot study included eight obese (BMI≥30) and eight lean (BMI<25) women undergoing clinically indicated mid-trimester genetic amniocentesis. Subjects were matched for gestational age and fetal sex. Fetuses with abnormal karyotype or structural anomalies were excluded. Cell-free fetal RNA was extracted from amniotic fluid and ..View full abstract
Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
This research was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awards R01 HD42053-10 and R01 HD058880. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.